ARMODAFINIL

What is armodafinil (Nuvigil) used for?

Armodafinil is commonly prescribed for narcolepsy and shift-work sleep disorder. It is a central nervous system (CNS) stimulant that impacts the brain and spinal cord; however, it has a low potential for abuse, unlike Adderall or Vyvanse, due to its pharmacokinetic properties [1].

 How can armodafinil help patients dealing with long COVID?

Some researchers theorize that neural pathways in the brain become distorted in long COVID. The initial infection caused by COVID-19 increases inflammation in the brain, which may leave cells vulnerable to other organisms or substances that may also cause inflammation. Continuation of this cycle can damage the signaling pathways between the cells in the brain. Over time, this results in the death of brain cells, leading to cognitive symptoms such as “brain fog.” Armodafinil may assist in rebuilding the destroyed pathways, leading to increased concentration and memory [1].

Additionally, as armodafinil is a CNS stimulant, it can promote wakefulness and decrease fatigue, something long COVID sufferers are all too familiar with [2]. Although more research needs to be completed regarding using armodafinil for long COVID, it does show promise in helping patients struggling with concentration, memory, and fatigue problems.           

References: 

¹https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp-rj.2022.170402

²https://journals.sagepub.com/doi/pdf/10.1177/10398562211003598