LISDEXAMFETAMINE

What is lisdexamfetamine, and how does it work?

Lisdexamfetamine is a stimulant medication that belongs to the drug class amphetamines. This medication acts on the central nervous system (CNS) by increasing levels of two chemicals, dopamine and norepinephrine, in the brain. Norepinephrine is thought to play a role in the body’s stress response and helps to regulate sleep, alertness, and blood pressure. Dopamine plays a crucial role in movement and affects motivation, perception of reality, and the ability to experience pleasure [1]. By increasing these levels of chemicals, it leads to an increase in focus and attention. Lisdexamfetamine is a controlled substance and does have the potential for abuse if used in a manner inconsistent with how it is prescribed.

How can lisdexamfetamine be used in long-COVID?

Sufferers of long-COVID often deal with “brain fog,” a persistent cognitive defect resulting in memory problems, poor focus, and decreased ability to concentrate. Although the reasoning is still unclear, researchers think COVID-19 may linger in the brain for months afterward. Even though it does not cause an active infection, it is a foreign substance in the body. This leads to constant attack by the immune system, causing inflammation. Over time, the continuous inflammation manifests as “brain fog” symptoms [2].

Stimulants, such as lisdexamfetamine, can improve focus, attention span, and even fatigue. A case study completed in 2022 showed benefits when using lisdexamfetamine, along with other agents, to help reduce “brain fog” [3]. Although there have been no formal studies conducted on using lisdexamfetamine for “brain fog,” one provider stated he has been using it, in conjunction with behavioral exercises, as a treatment option. He saw improved memory, attention, fatigue, and concentration difficulties [4].

Although current recommendations do not advocate for the use of stimulants to treat long-COVID or symptoms of long-COVID, for those suffering from “brain fog” or fatigue, it may be an attractive option to those looking for symptom management.

References:

¹https://americanaddictioncenters.org/antidepressants-guide/ndris#

²https://www.unmc.edu/healthsecurity/transmission/2023/02/14/long-covid-now-looks-like-a-neurological-disease-helping-doctors-to-focus-treatments/

³https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102822/

⁴https://www.ohsu.edu/sites/default/files/2023-02/PCR23-Mon-18-AndersonWM.pdf