MAGNESIUM THREONATE

What is magnesium threonate?

Magnesium threonate is a form of magnesium that is more easily absorbed by the body than magnesium. The compound threonate is a supplement that makes magnesium more bioavailable in the body. Magnesium is an essential mineral in the body that is required to synthesize all B vitamins except vitamin B7 (biotin).

What does magnesium threonate do in the body?

Mitochondrial activity depends on B vitamins [^[1]]. The body uses magnesium for physiologic functions and biochemical reactions. Magnesium may have anti-inflammatory, anti-oxidant effects. Magnesium supplements prevent damage to organs and tissues through multiple means; they are also anticholinergic, antihistamine, and anti-inflammatory. Magnesium supports lung function by reducing airway hyperreactivity and wheezing and promoting bronchodilation [^[2]]. Magnesium plays a role in respiratory symptoms, reducing inflammation and restoring electrolyte abnormalities in COVID-19 [^[2]].

How can magnesium threonate help alleviate certain Long COVID symptoms and/or pathophysiology? 

Magnesium deficiency can be frequent in the intensive care unit, where it is linked to increased mortality, greater need for a ventilator, sepsis, and more extended hospital stays. Therefore, researchers believe magnesium deficiency could be associated with acute COVID-19 infection severity. In COVID-19 patients, magnesium supplementation prevents lung fibrosis, a rare but severe complication of COVID-19. Magnesium deficiency is also, more generally, associated with low-grade chronic inflammation. It also plays a role in maintaining endothelial and vascular function [^[2]]. Magnesium also plays a recovery role in the post-acute phase of COVID-19 [^[3]]. Magnesium supplementation in long COVID patients could help improve endothelial and vascular function and help protect against inflammation. Magnesium deficiency is linked to cognitive difficulties, post-exertional malaise, headache, dizziness, myalgia, and asthma in Long COVID [^[4]].

Lastly, magnesium metabolism is also linked to vitamin D, which is also often recommended for Long COVID patients, and a vitamin D deficiency-associated problem cannot be corrected without enough magnesium [^[4]].