MODAFANIL

What is modafinil (Provigil) used for?

Modafinil is commonly prescribed for narcolepsy and shift-work sleep disorder. It is a central nervous system (CNS) stimulant in that its effects are within the brain and spinal cord; however, it has a low potential for abuse, unlike Adderall or Vyvanse, due to its pharmacokinetic properties [1].

How can modafinil help patients dealing with long-COVID?

Researchers’ theory in long-COVID says that pathways in the brain become distorted. The initial infection caused by COVID-19 increases inflammation in the brain, leaving the cells vulnerable to other organisms or substances that may also cause inflammation. This cycle continues and destroys the signaling pathways between the cells in the brain. Over time, this results in the death of brain cells, leading to “brain fog.” Since those with long-COVID suffer from inflammation, armodafinil may assist in rebuilding the destroyed pathways, leading to increased concentration and memory [1].

Additionally, modafinil is a CNS stimulant that can promote wakefulness and decrease fatigue, something long-COVID sufferers are all too familiar with [2]. Although more research needs to be completed regarding the use of modafinil for long-COVID, it does show promise in helping patients struggling with concentration, memory, and fatigue problems.

References:

¹https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp-rj.2022.170402

²https://journals.sagepub.com/doi/pdf/10.1177/10398562211003598