MEXIDOL

What is Mexidol?

Emoxypine succinate, also known by its commercial name Mexidol, is a chemical resembling Vitamin B6 (pyridoxine). Mexidol has many effects on the nervous and vascular systems. While available in Russia, Mexidol is generally unknown elsewhere [^[1]].

What does Mexidol do in the body?

Mexidol’s effects are diverse because its mechanism of action involves both antioxidant effects and actions at cell membranes. Some actions of Mexidol include that it protects against hypoxia (oxygen deficiency) and ischemia (inadequate blood supply to organs and other body parts, especially heart muscles). Mexidol is also anti-stress, anti-anxiety, anti-convulsant, anti-aging, neuroprotective, cardioprotective, and protective against forming fatty plaques in the arteries [^[1]]. Lastly, Mexidol has been met with some success in treating mental disorders without any significant side effects [^[2]].

How can Mexidol help alleviate certain Long COVID symptoms and pathophysiology? 

As a multitasking compound, Mexidol can act on many aspects of COVID-10 pathogenesis, including Long COVID. Researchers believe Mexidol can reduce brain inflammation and free radical oxidation [^3]]. Long COVID has post-viral brain symptoms often referred to as “brain fog,” which involves heightened free radical activity in the brain, as well as decreased blood flow in the brain due to activation of the brain’s resident immune cells, as well as altered blood flow more generally [^[4]]. Mexidol’s anti-inflammatory and neuroprotective properties may help combat these issues.

Features of acute and chronic COVID-19, such as endothelial dysfunction, increased blood clotting, accumulation of angiotensin 2, endothelial problems, overactivation of inflammatory cytokines, and too much inflammation, are issues that Mexidol can improve. Mexidol improves outcomes after ischemic stroke, which may be useful for Long COVID and its associated endothelial, cardiovascular, and pulmonary inflammatory issues [^[2]].