SYSTEMIC PROTEOLYTIC ENZYMES 

What are systemic proteolytic enzymes?                                                                                            

We previously discussed bromelain’s utility in reducing inflammation. Bromelain, discussed in this guide, belongs to a larger class of systemic proteolytic enzymes, or SPEs. SPEs break down proteins to help facilitate normal body processes such as digestion or pain relief. They can also be used to reduce swelling and help with wound healing cleanup [^[1]].

Other SPEs include lysozyme, catalase, and papain. SPEs break down proteins into smaller fragments and, ultimately, into amino acids, which are the building blocks of proteins and other vital molecules the body uses for various purposes [^[2]].

What do systemic proteolytic enzymes do in the body?

SPEs can be taken as oral supplements or applied to the skin. Applied to the skin, they can aid in cleaning up tissue from wounds to support healthy wound healing [^[1]].

As a supplement, SPEs can work in the body to perform a variety of processes related to immune health, digestion, and more. Regarding COVID-19 and its impact on the immune system in Long COVID, SPEs are known immune system modulators. SPEs work to combat oxidative stress and prevent cell and tissue damage [^[2]].

How can systemic proteolytic enzymes help alleviate certain Long COVID symptoms and pathophysiology? 

SPEs may be able to break down the spike proteins in SARS-CoV-2, the virus that causes COVID-19 [^[2]]. They may also be able to unfold coronavirus proteins. SPE’s antiviral properties can be helpful because the virus can persist in Long COVID patients after the acute phase.