Pregnancy

Prolonged experience with mirtazapine in pregnant women, based on published observational studies and postmarketing reports, has not reliably identified a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes

Lactation

The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for mirtazapine and any potential adverse effects on the breastfed infant from mirtazapine or from the underlying maternal condition

Warnings

Black Box Warnings: Suicidal thoughts in children and adolescents taking antidepressants ; Contraindicated: MAOIs, hypersensitivity ; Warnings: Agranulocytosis, serotonin syndrome, angle-closure glaucoma, QT prolongation, increased appetite, somnolence, hyponatremia, activated mania/hypomania, seizures, elevated triglycerides/cholesterol, transaminase elevations