TROXERUTIN

What is troxerutin?

Troxerutin is a flavonoid in foods, including coffee and tea, cereals, fruits, and vegetables [^[1]]. A flavonoid is a chemical compound found in plants, fruits, and vegetables that can have medicinal applications. Troxerutin is derived from the plant pigment rutin, which has several medicinal properties [^[2]].

What does troxerutin do in the body?

Troxerutin’s diverse health effects come from its role as an antioxidant, anti-inflammatory, antidiabetic, and anti-clotting substance. It is also protective of the nervous system and kidneys. As an antioxidant, troxerutin works by scavenging free radicals in the body. Some of its antioxidant functions come from its ability to enhance the activity of other antioxidants, such as glutathione and superoxide dismutase. Troxerutin helps epithelial cells, connective tissue, and white blood cells escape cell death resulting from oxidative stress. Troxerutin also helps protect the kidneys and the brain’s hippocampus from stress-induced damage [^[1]]. In animal studies, troxerutin inhibited obesity, normalized high blood sugar, and improved lipid (fat) balance in the liver by protecting against NAD+ depletion, thereby reducing inflammation and promoting healthy NAD+ levels [^[3]].

How can troxerutin help alleviate certain Long COVID symptoms and pathophysiology? 

More data is needed to examine the activity of troxerutin in acute COVID-19 infection and Long COVID. However, due to its role as an antioxidant and anti-inflammatory compound, troxerutin remains a potentially helpful medicinal compound for both acute and chronic consequences of COVID-19 [^1]]. Given that Long COVID involves both the nervous system, vascular endothelium, and kidneys, and troxerutin supports the health of endothelial cells as well as the brain and kidneys, troxerutin could be a promising supplement [^[4]].