Sertraline

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Brand Name: Zoloft

Drug Class: Antidepressant (SSRI)

FDA Category: Prescription Medication

CompendiRx Topic(s): Mental Health

Dosage Form: Tablet Tablets - 25mg, 50mg, 100mg ; Capsules - 150mg, 200mg ; Oral solution - 20mg/mL

Common Usage: Depression, obsessive compulsive disorder (OCD), social anxiety disorder (SAD), posttraumatic stress disorder (PTSD), panic disorder (PD), premenstrual dysphoric disorder (PMDD)

How it works

Blocks the reuptake of serotonin

Pregnancy

When treating a pregnant woman with sertraline during the third trimester, carefully consider both the potential risks and benefits of treatment. Monitor neonates who were exposed to sertraline in the third trimester of pregnancy for persistent pulmonary hypertension of the newborn and drug discontinuation syndrome

Lactation

There are no data on the effects of sertraline on milk production. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for sertraline and any potential adverse effects on the breastfed infant from the drug or from the underlying maternal condition.

Warnings

Black Box Warning: Increased risk of suicidal thoughts in children and adolescents. Closely monitor for clinical worsening or emergency of suicidal thoughts or behaviors ; Contraindicated: Concomitant use of MAOIs, concomitant use of pimozide, hypersensitivity, oral solution: concomitant use of disulfiram ; Warnings: serotonin syndrome, increased risk of bleeding with NSAIDS, seizures, angle closure glaucoma, QT prolongation, sexual dysfunction, activation of mania/hypomania

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