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Treatment Details

Simvastatin

Brand Name: Zocor
Drug Class: Statin (HMG-CoA reductase…
FDA Category: Prescription Medication
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Overview

SIMVASTATIN   What is simvastatin (Zocor). Simvastatin is part of a class of drugs commonly referred to as statins. Its role is to reduce the amount of cholesterol the liver makes. Cholesterol comprises HDL, the “good” cholesterol, and LDL, the “bad” cholesterol. The body uses cholesterol to make various hormones and other substances. However, if a person has too much LDL, it can cause a buildup in the arteries, leading to stroke, heart attack, or other health problems.

Relevant Studies

PMC9520195 – www.ncbi.nlm.nih.gov

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Article – journals.plos.org

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2780872 – jamanetwork.com

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How it works:

Inhibits HMG-CoA reductase during cholesterol synthesis in the liver

Dosage Form: Tablet Tablet - 5mg, 10mg, 20mg, 40mg , Oral solution - 4mg/mL, 8mg/mL

Common Usage: Lowering cholesterol, Prevention of cardiovascular events

Precautions:

Pregnancy

Simvastatin may cause fetal harm when administered to pregnant patients based on the mechanism of action. Discontinue simvastatin when pregnancy is recognized. Alternatively, consider the ongoing therapeutic needs of the individual patient

Lactation

Because of the potential for serious adverse reactions in a breastfed infant, based on the mechanism of action, advise patients that breastfeeding is not recommended during treatment with simvastatin

Warnings

"Contraindicated: Hypersensitivity to simvastatin, active liver disease or unexplained transaminase elevations, pregnancy, lactation Warnings: Strong CYP3A4 inhibitors, myopathy, rhabdomyolysis, liver enzyme abnormalities"

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© 2024 CompendiRx.com. All Rights Reserved. Information on Ratings and Reviews is reported by our members and is not medical advice.

Submission Date: Apr 16, 2024, 07:21AM

Last Update Date: Sep 15, 2024, 03:14AM