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Treatment Details

Zileuton

Brand Name: Zyflo
Drug Class: Leukotriene synthesis inhibitor
FDA Category: Prescription Medication
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Overview

ZILEUTON   What is zileuton (Zyflo). Zileuton is part of a class of medications known as leukotriene receptor antagonists. Leukotrienes, specifically LTC4, LTD4, and LTE4, are pro-inflammatory mediators heavily involved in the mechanisms behind asthma. When provoked, leukotrienes constrict the airways, making breathing harder. Zileuton blocks leukotrienes from closing the airways, effectively making breathing easier.    What is the relationship between zileuton and long-COVID. For patients suffering from inflammatory respiratory symptoms of long-COVID such as wheezing, cough, exercise intolerance, and trouble breathing, zileuton may play a role in mitigating these symptoms [1].

Relevant Studies

Full – www.frontiersin.org

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S43168 022 00154 6 – doi.org

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How it works:

5-lipoxygenase inhibitor

Dosage Form: Tablet Tablet (IR) - 600mg , Tablet (ER) - 600mg

Common Usage: Asthma

Precautions:

Pregnancy

There are no adequate human data on zileuton extended-release tablets use in pregnant women to inform a drug associated risk.

Lactation

the developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for zileuton extended-release tablets and any potential adverse effects on the breastfed child from zileuton extended-release tablets or from the underlying maternal condition

Warnings

Contraindicated: Hypersensitivity, active liver disease, transaminase levels ≥3xULN , Warnings: Not indicated for acute bronchospasm, may elevate liver levels, watch for neuropsychiatric events in children and adolescents

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© 2024 CompendiRx.com. All Rights Reserved. Information on Ratings and Reviews is reported by our members and is not medical advice.

Submission Date: Apr 16, 2024, 07:25AM

Last Update Date: Sep 14, 2024, 07:27PM