Duloxetine

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Most-Reviewed Use: ANTIBIOTICS

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Brand Name: Cymbalta, Yentreve

Drug Class: Antidepressant (SNRI)

FDA Category: Prescription Medication

CompendiRx Topic(s): Mental Health

Dosage Form: Tablet Capsule (DR) - 20mg, 30mg, 40mg, 60mg

Common Usage: Depression, anxiety, diabetic peripheral neuropathic pain, fibromyalgia

How it works

Blocks the reuptake of serotonin and norepinephrine

Pregnancy

Data from a postmarketing retrospective cohort study indicate that use of duloxetine in the month before delivery may be associated with an increased risk of postpartum hemorrhage. Data from published literature and from a postmarketing retrospective cohort study have not identified a clear drug-associated risk of major birth defects or other adverse developmental outcomes

Lactation

The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for duloxetine and any potential adverse effects on the breastfed child from duloxetine or from the underlying maternal condition

Warnings

Black Box Warning: Increased risk of suicidal thoughts in children and adolescents taking antidepressants ; Contraindicated: Concomitant use of MAOIs, concomitant use of linezolid or IV methylene blue ; Warnings: Hepatotoxicity, orthostatic hypotension, serotonin syndrome, increased risk of bleeding, severe skin reactions, activation of mania/hypomania, risk of seizures, risk of open angle glaucoma, hyponatremia, blood sugar increases, sexual dysfunction, blood pressure increases, CYP1A2 inhibitors

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